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IKB-α Polyclonal Antibody (CAB24742)

SKU:
CAB24742
€259
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:IKB-α Polyclonal Antibody
SKU:CAB24742
Size:100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IκBα (NP_065390.1).
Sequence:MFQA AERP QEWA MEGP RDGL KKER LLDD RHDS GLDS MKDE EYEQ MVKE LQEI RLEP QEVP RGSE PWKQ QLTE DGDS FLHL AIIH EEKA LTME VIRQ VKGD
Tested Applications:WB
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:IKBA; MAD-3; NFKBI; EDAID2; IKB-α
Positive Sample:Jurkat,HeLa,NIH/3T3,Rat thymus,PC-12
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:36kDa
Observed MW:39kDa

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Purification Method:Affinity purification
Gene ID:4792
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using IKB-α Rabbit pAb (CAB24742) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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