The Ikaros Rabbit Monoclonal Antibody (CAB3565) is a cutting-edge tool for researchers studying Ikaros, a transcription factor known for its role in regulating gene expression and cellular differentiation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Ikaros in various biological samples, making it a valuable asset for immunology and cancer research.Ikaros is a key player in controlling the development and function of immune cells, making it a potential target for therapeutic interventions in immune-related diseases such as leukemia and autoimmune disorders.
By accurately detecting and analyzing Ikaros protein levels, researchers can gain insights into its function and explore its potential as a biomarker or therapeutic target in various disease contexts.Overall, the Ikaros Rabbit Monoclonal Antibody (CAB3565) offers researchers a reliable tool for investigating the role of Ikaros in immune regulation and disease pathogenesis, opening up new avenues for developing targeted therapies and personalized medicine approaches.
Product Name:
Ikaros Rabbit Monoclonal Antibody
SKU:
CAB3565
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Ikaros (Q13422).
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
Purification Method:
Affinity purification
Gene ID:
10320
Clone Number:
ARC0803
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
CUT&Tag was performed using the CUT&Tag Assay Kit (pAG-Tn5) for Illumina(RK20265) from 10⁵ K562 cells with 1 μg Ikaros Rabbit mAb (CAB3565), along with a Goat Anti-Rabbit IgG(H+L). The CUT&Tag results indicate the enrichment pattern of Ikaros in representative gene loci (MICA), as shown in figure.