The IHH Polyclonal Antibody (CAB6626) is a powerful tool for researchers studying IHH, a key signaling molecule involved in the development and maintenance of various tissues and organs in the body. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the IHH protein, this antibody enables precise detection and analysis in a variety of cell types, making it an invaluable asset for studies in developmental biology, regenerative medicine, and cancer research.IHH, also known as Indian hedgehog protein, plays a crucial role in embryonic development, cell differentiation, and tissue regeneration.
Dysregulation of the IHH signaling pathway has been linked to various developmental disorders, skeletal deformities, and cancer progression. By elucidating the molecular mechanisms of IHH function, researchers can gain insights into potential therapeutic targets for conditions ranging from birth defects to cancer metastasis.Overall, the IHH Polyclonal Antibody (CAB6626) offers researchers a reliable tool to investigate the intricate functions of IHH and its implications in health and disease. Its versatility and specificity make it an essential component of any study aiming to unravel the complexities of developmental biology and therapeutic interventions.
Product Name:
IHH Rabbit Polyclonal Antibody
SKU:
CAB6626
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 202-411 of human IHH (NP_002172.2).
This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
Purification Method:
Affinity purification
Gene ID:
3549
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IHH antibody (CAB6626) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
