The IGSF10 Monoclonal Antibody (PACO14564) is a valuable tool for researchers studying IGSF10, a cell surface protein with diverse functions in cell adhesion and signaling pathways. This antibody, produced through a careful monoclonal process, exhibits high specificity and sensitivity for detecting IGSF10 in human samples. Validated for use in various applications including Western blot and immunohistochemistry, this antibody allows for precise detection and analysis of IGSF10 expression in different cell types.IGSF10, also known as Immunoglobulin Superfamily Member 10, is known to play a key role in cell-cell interactions and has been implicated in a range of physiological processes.
Its involvement in signaling cascades and adhesion mechanisms make it a promising target for investigations in cell biology, cancer research, and developmental biology. By understanding the functions and regulation of IGSF10, researchers can gain insights into its contribution to disease pathology and potentially identify new therapeutic strategies for various disorders.Overall, the IGSF10 Monoclonal Antibody (PACO14564) offers a valuable tool for researchers looking to explore the roles of IGSF10 in different contexts, paving the way for advancements in biomedical research and potential clinical applications.
Antibody Name:
IGSF10 Antibody (PACO14564)
Antibody SKU:
PACO14564
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human IGSF10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14564(IGSF10 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Ig (immunoglobulin) superfamily members exhibit functional characteristics including immune responses, growth factor signaling and cell adhesion. IGSF10 (immunoglobulin superfamily, member 10), also known as Calvaria mechanical force protein 608 (CMF608), is a 2,623 amino acid, secreted protein that contains an N-terminal signal peptide, six leucine-rich repeats (LRRs), and 12 immunoglobulin-like repeats. IGSF10 exists as multiple alternatively spliced isoforms, and is expressed in bone. Specifically, expression of IGSF10 is limited to mesenchymal osteochondroprogenitors with fibroblast-like morphology, where it is thought to be involved in the maintenance of the osteochondroprogenitor cells pool and its down-regulation precedes terminal differentiation.
Synonyms:
immunoglobulin superfamily, member 10
UniProt Protein Function:
IGSF10: May be involved in the maintenance of osteochondroprogenitor cells pool. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Immunoglobulin superfamily; Secreted, signal peptide; Protein kinase, tyrosine (receptor); Kinase, protein; SecretedChromosomal Location of Human Ortholog: 3q25.1Cellular Component: extracellular regionBiological Process: ossification; multicellular organismal development; cell differentiation
