The IGLL1, IGLC1, IGLC2, IGLC3, IGLC6, and IGLC7 Antibody (PACO00550) is an essential tool for researchers studying the immunoglobulin lambda light chain (IGLC) gene family. This polyclonal antibody, raised in rabbits, specifically targets the IGLL1, IGLC1, IGLC2, IGLC3, IGLC6, and IGLC7 proteins, allowing for accurate detection and analysis in a variety of cell types.The IGLC gene family encodes the lambda light chains of antibodies, which play a crucial role in the immune response by binding to antigens and initiating immune reactions. The IGLL1, IGLC1, IGLC2, IGLC3, IGLC6, and IGLC7 proteins are important components of the immune system and are involved in antibody function.
This antibody is validated for use in Western blot applications and is highly reactive with human samples, making it an ideal choice for researchers working in immunology, oncology, and antibody research. By targeting the IGLL1, IGLC1, IGLC2, IGLC3, IGLC6, and IGLC7 proteins, this antibody provides valuable insights into the function and regulation of the IGLC gene family, ultimately contributing to our understanding of the immune system and potential
Antibody Name:
IGLL1/IGLC1/IGLC2/IGLC3/IGLC6/IGLC7 Antibody
Antibody SKU:
PACO00550
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human CD179b.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
IGLL1; IGL1; Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD antigen CD179b; IGLC1; Ig lambda-1 chain C regions; IGLC2; Ig
UniProt Protein Function:
IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 22q11.23Cellular Component: external side of plasma membrane; membraneMolecular Function: antigen bindingBiological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; immune response; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activationDisease: Agammaglobulinemia 2, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
