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IGLL1/IGLC1/IGLC2/IGLC3/IGLC6/IGLC7 Antibody (PACO00550)

SKU:
PACO00550
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Antibody Name:IGLL1/IGLC1/IGLC2/IGLC3/IGLC6/IGLC7 Antibody
Antibody SKU:PACO00550
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the N-terminal region of human CD179b.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:IGLL1; IGL1; Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD antigen CD179b; IGLC1; Ig lambda-1 chain C regions; IGLC2; Ig
UniProt Protein Function:IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 22q11.23Cellular Component: external side of plasma membrane; membraneMolecular Function: antigen bindingBiological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; immune response; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activationDisease: Agammaglobulinemia 2, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P15814
NCBI GenInfo Identifier:123944
NCBI Gene ID:3543
NCBI Accession:P15814.1
UniProt Secondary Accession:P15814,Q0P681
UniProt Related Accession:P15814
Molecular Weight:8,574 Da
NCBI Full Name:Immunoglobulin lambda-like polypeptide 1
NCBI Synonym Full Names:immunoglobulin lambda like polypeptide 1
NCBI Official Symbol:IGLL1  
NCBI Official Synonym Symbols:IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1  
NCBI Protein Information:immunoglobulin lambda-like polypeptide 1
UniProt Protein Name:Immunoglobulin lambda-like polypeptide 1
UniProt Synonym Protein Names:CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD_antigen: CD179b
Protein Family:Ig lambda chain C region
UniProt Gene Name:IGLL1  
UniProt Entry Name:IGLL1_HUMAN

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