The IGHMBP2 Polyclonal Antibody (CAB16053) is a valuable tool for researchers studying IGHMBP2, a protein involved in DNA and RNA binding as well as ATP-dependent RNA helicase activity. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the IGHMBP2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for research in molecular biology and genetics.IGHMBP2 is known for its role in maintaining mitochondrial and nuclear genome stability, as well as its involvement in DNA replication and transcription.
Mutations in the IGHMBP2 gene have been associated with neurodegenerative disorders such as distal spinal muscular atrophy and Charcot-Marie-Tooth disease, highlighting the importance of studying this protein in the context of human health and disease. Understanding the functions of IGHMBP2 can provide insights into the underlying mechanisms of these disorders and potentially lead to the development of targeted therapies.
Product Name:
IGHMBP2 Rabbit Polyclonal Antibody
SKU:
CAB16053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human IGHMBP2 (NP_002171.2).
This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1.
Purification Method:
Affinity purification
Gene ID:
3508
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGHMBP2 Rabbit pAb (CAB16053) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
