The IGFBP7 Polyclonal Antibody (CAB13023) is a valuable tool for researchers studying IGFBP7, a protein that plays a crucial role in various biological processes, including cell growth, differentiation, and apoptosis. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.IGFBP7, also known as insulin-like growth factor binding protein 7, is involved in regulating the bioavailability and activity of insulin-like growth factors, which are key regulators of cell growth and survival. Dysregulation of IGFBP7 has been linked to various diseases, including cancer and cardiovascular disorders, making it a promising target for therapeutic intervention.
By specifically binding to IGFBP7, this polyclonal antibody enables researchers to detect and analyze the protein in various cell types, providing valuable insights into the mechanisms underlying its biological functions. Studying the role of IGFBP7 is essential for advancing our understanding of disease pathogenesis and developing novel treatment strategies targeting this important signaling molecule.
Product Name:
IGFBP7 Rabbit Polyclonal Antibody
SKU:
CAB13023
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-282 of human IGFBP7 (NP_001544.1).
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
Purification Method:
Affinity purification
Gene ID:
3490
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGFBP7 Rabbit pAb (CAB13023) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
