The IGFBP5 Polyclonal Antibody (CAB12451) is a valuable tool for researchers studying Insulin-like Growth Factor Binding Protein 5 (IGFBP5), a key player in cell growth and development processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to IGFBP5, it enables precise detection and analysis of this protein in various cell types, making it well-suited for investigations in the fields of molecular biology and cancer research.
IGFBP5 is known to interact with insulin-like growth factors (IGFs) and modulate their activity, impacting cell proliferation, differentiation, and survival. Dysregulation of IGFBP5 has been implicated in various diseases, including cancer and metabolic disorders, emphasizing its importance as a potential therapeutic target. Research on IGFBP5 can provide insights into the underlying mechanisms of these diseases and guide the development of targeted treatment strategies aimed at restoring normal cell growth and function.
Product Name:
IGFBP5 Rabbit Polyclonal Antibody
SKU:
CAB12451
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 68-167 of human IGFBP5 (NP_000590.1).
Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis.
Purification Method:
Affinity purification
Gene ID:
3488
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using IGFBP5 Rabbit pAb (CAB12451) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
