The IGFBP4 Polyclonal Antibody (CAB2008) is a valuable tool for researchers studying Insulin-Like Growth Factor Binding Protein 4 (IGFBP4), a protein involved in regulating cell growth and survival. This antibody, produced in rabbits, is highly specific for human samples and is suitable for use in Western blotting applications. By binding to IGFBP4, this antibody enables the detection and analysis of IGFBP4 protein levels in various cell types, making it an essential reagent for studies in cancer biology, developmental biology, and endocrinology.IGFBP4 is known to interact with insulin-like growth factors and modulate their activity, influencing processes such as cell proliferation, differentiation, and apoptosis.
Dysregulation of IGFBP4 expression has been linked to various diseases, including cancer, cardiovascular disorders, and metabolic syndromes. By using the IGFBP4 Polyclonal Antibody, researchers can investigate the role of IGFBP4 in these pathological conditions and potentially identify novel therapeutic targets for intervention. Understanding the function of IGFBP4 is crucial for advancing our knowledge of cellular signaling pathways and developing targeted therapies for diseases associated with abnormal cell growth and metabolism.
Product Name:
IGFBP4 Rabbit Polyclonal Antibody
SKU:
CAB2008
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-258 of human IGFBP4 (NP_001543.2).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Purification Method:
Affinity purification
Gene ID:
3487
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGFBP4 Rabbit pAb (CAB2008) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
