The IGFBP4 Polyclonal Antibody (CAB15068) is a powerful tool for researchers studying IGFBP4, a protein involved in regulating the activity of insulin-like growth factors (IGFs). This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it an excellent choice for Western blot applications. By binding to IGFBP4, it facilitates the detection and analysis of this important regulatory protein in various cell types, making it an invaluable resource for studies focusing on growth regulation and cancer biology.
IGFBP4, a member of the insulin-like growth factor binding protein family, plays a crucial role in modulating the effects of IGFs on cell growth, differentiation, and survival. Dysregulation of IGFBP4 expression has been implicated in various diseases, including cancer, diabetes, and cardiovascular disorders, highlighting its potential as a therapeutic target. By investigating the function of IGFBP4, researchers can gain insights into the mechanisms underlying these diseases and explore new avenues for intervention and treatment.
Product Name:
IGFBP4 Rabbit Polyclonal Antibody
SKU:
CAB15068
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 178-258 of human IGFBP4 (NP_001543.2).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Purification Method:
Affinity purification
Gene ID:
3487
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGFBP4 Rabbit pAb (CAB15068) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
