The IGFBP3 Polyclonal Antibody (CAB16052) is a valuable tool for researchers studying IGFBP3, a key protein involved in regulating the bioavailability of insulin-like growth factors. The antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the IGFBP3 protein, this antibody allows for the detection and analysis of IGFBP3 in various types of cells, making it ideal for studies in endocrinology and cancer research.IGFBP3, also known as insulin-like growth factor-binding protein 3, plays a crucial role in modulating the effects of insulin-like growth factors on cell growth and metabolism.
Its dysregulation has been implicated in various diseases, including cancer, diabetes, and cardiovascular disorders. By studying the function of IGFBP3, researchers can gain insights into the mechanisms underlying these conditions and develop targeted therapies to address them.Overall, the IGFBP3 Polyclonal Antibody is a valuable tool for investigating the role of IGFBP3 in health and disease. Its high specificity and sensitivity make it a reliable option for researchers looking to advance our understanding of insulin-like growth factor regulation and its implications for human health.
Product Name:
IGFBP3 Rabbit Polyclonal Antibody
SKU:
CAB16052
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human IGFBP3 (NP_000589.2).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
3486
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IGFBP3 antibody (CAB16052) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
