The IGFBP1 Rabbit Monoclonal Antibody is a highly specific and sensitive tool for studying IGFBP1, a protein involved in the regulation of insulin-like growth factor signaling and metabolism. This antibody, derived from rabbits, has been validated for use in various research applications, including Western blotting and immunohistochemistry.IGFBP1, also known as insulin-like growth factor-binding protein 1, is a key player in the growth hormone axis and has been implicated in various physiological processes, such as cell proliferation, differentiation, and survival. Dysregulation of IGFBP1 has been associated with conditions like diabetes, cardiovascular disease, and cancer, making it a promising target for therapeutic intervention.
By utilizing the IGFBP1 Rabbit Monoclonal Antibody, researchers can gain insights into the expression levels and localization of IGFBP1 in different cell types and tissues, advancing their understanding of the protein's function and potential implications in health and disease. This antibody is a valuable tool for studies in endocrinology, metabolism, and cancer biology, providing researchers with a reliable and efficient means of investigating the role of IGFBP1 in various biological processes.
Product Name:
IGFBP1 Rabbit Monoclonal Antibody
SKU:
CAB11672
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 160-259 of human IGFBP1 (P08833).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Purification Method:
Affinity purification
Gene ID:
3484
Clone Number:
ARC0671
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using IGFBP1 Rabbit mAb (CAB11672) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
