The IGFBP1 Polyclonal Antibody (CAB2981) is a valuable tool for researchers studying insulin-like growth factor binding protein 1 (IGFBP1), a key regulator of insulin-like growth factors in the body. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the IGFBP1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential tool for investigations in the fields of endocrinology and metabolism.IGFBP1 is known to play a crucial role in mediating the actions of insulin-like growth factors, which are implicated in various physiological processes such as growth, development, and metabolism.
Dysregulation of IGFBP1 has been associated with conditions like diabetes, obesity, and certain types of cancer, highlighting its importance as a potential biomarker and therapeutic target. By studying the function of IGFBP1 using this polyclonal antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new treatment strategies.
Product Name:
IGFBP1 Rabbit Polyclonal Antibody
SKU:
CAB2981
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 81-259 of human IGFBP1 (NP_000587.1).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Purification Method:
Affinity purification
Gene ID:
3484
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using IGFBP1 antibody (CAB2981) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
