The IGFALS Polyclonal Antibody (CAB10223) is a research tool specifically designed for studying IGFALS, a protein involved in the regulation of insulin-like growth factors. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot assays. By targeting the IGFALS protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for investigations in endocrinology and growth factor signaling.IGFALS, also known as insulin-like growth factor-binding protein complex acid labile subunit, plays a crucial role in the binding and transport of insulin-like growth factors in the bloodstream.
Its function in regulating the bioavailability and activity of these growth factors highlights its relevance in studies on growth disorders, metabolic diseases, and hormonal regulation. By elucidating the mechanisms of IGFALS action, researchers can uncover new insights into the pathophysiology of conditions such as diabetes, growth hormone deficiencies, and metabolic syndrome, ultimately leading to the development of targeted therapeutic strategies.
Product Name:
IGFALS Rabbit Polyclonal Antibody
SKU:
CAB10223
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 396-605 of human IGFALS (NP_004961.1).
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3483
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IGFALS antibody (CAB10223) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
