The IGF2R Polyclonal Antibody (CAB13022) is a vital tool for researchers studying the Insulin-like Growth Factor 2 Receptor (IGF2R) protein. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By targeting the IGF2R protein, this antibody enables researchers to detect and analyze IGF2R levels in various cell types, providing valuable insights into the role of IGF2R in cellular processes related to growth and development.IGF2R is a key receptor involved in the regulation of insulin-like growth factors, playing a crucial role in growth inhibition and tumor suppression. Studies have shown that dysregulation of IGF2R expression is associated with various diseases, including cancer and developmental abnormalities.
By using the IGF2R Polyclonal Antibody, researchers can gain a better understanding of the molecular mechanisms underlying these diseases and explore potential therapeutic interventions targeting IGF2R signaling pathways.Overall, the IGF2R Polyclonal Antibody (CAB13022) is a valuable tool for researchers interested in investigating the functions of the IGF2R protein and its implications in disease pathology. Its high specificity and reactivity make it a reliable asset in studies related to cancer, growth regulation, and other cellular processes involving the IGF2R protein.
Recombinant fusion protein containing a sequence corresponding to amino acids 2327-2491 of human Cation-independent M6PR (Cation-independent M6PR (IGF2R)) (NP_000867.2).
Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
274kDa
Observed MW:
274kDa
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Purification Method:
Affinity purification
Gene ID:
3482
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using Cation-independent M6PR (IGF2R) Rabbit pAb (CAB13022) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
