Cation-independent M6PR (IGF2R) Rabbit Polyclonal Antibody (CAB13022)
- SKU:
- CAB13022
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | Cation-independent M6PR (IGF2R) Rabbit Polyclonal Antibody |
SKU: | CAB13022 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2327-2491 of human Cation-independent M6PR (Cation-independent M6PR (IGF2R)) (NP_000867.2). |
Sequence: | YKKE RRET VISK LTTC CRRS SNVS YKYS KVNK EEET DENE TEWL MEEI QLPP PRQG KEGQ ENGH ITTK SVKA LSSL HGDD QDSE DEVL TIPE VKVH SGRG AGAE SSHP VRNA QSNA LQER EDDR VGLV RGEK ARKG KSSS AQQK TVSS TKLV SFHD DSDE DLLH I |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R; Cation-independent M6PR (IGF2R) |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome membrane, Single-pass type I membrane protein. |
Calculated MW: | 274kDa |
Observed MW: | 274kDa |
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Purification Method: | Affinity purification |
Gene ID: | 3482 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |