The IGF2BP3 Polyclonal Antibody (CAB2750) is a valuable tool for researchers studying IGF2BP3, a protein involved in the regulation of mRNA translation and stability. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.IGF2BP3, or insulin-like growth factor 2 mRNA-binding protein 3, plays a crucial role in post-transcriptional regulation of gene expression, particularly in the context of cancer development and progression. By targeting IGF2BP3, researchers can investigate its involvement in various cellular processes, making it a versatile tool for studies in cancer biology and RNA metabolism.
Understanding the function of IGF2BP3 is essential for developing targeted therapies for cancer and other diseases where dysregulation of mRNA binding proteins is implicated. The IGF2BP3 Polyclonal Antibody (CAB2750) offers researchers a reliable means of detecting and analyzing IGF2BP3 expression in different cell types, allowing for in-depth exploration of its role in disease mechanisms.
Product Name:
IGF2BP3 Rabbit Polyclonal Antibody
SKU:
CAB2750
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human IGF2BP3 (NP_006538.2).
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
Purification Method:
Affinity purification
Gene ID:
10643
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IGF2BP3 antibody (CAB2750) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
