The IGF2BP2 Polyclonal Antibody (CAB14103) is a powerful tool for researchers studying IGF2BP2, a key protein involved in mRNA stability and translation regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, and has been validated for use in Western blot applications.IGF2BP2, also known as insulin-like growth factor 2 mRNA-binding protein 2, is a critical player in post-transcriptional gene expression control, impacting processes such as cell proliferation, differentiation, and metabolism.
Dysregulation of IGF2BP2 has been implicated in various diseases, particularly cancer and metabolic disorders.By targeting IGF2BP2, researchers can gain insights into the molecular mechanisms underlying these diseases, potentially leading to the development of novel therapeutic approaches. This antibody provides a valuable tool for studying the role of IGF2BP2 in different cell types and conditions, offering new opportunities for advancements in biomedical research.
Product Name:
IGF2BP2/IMP2 Rabbit Polyclonal Antibody
SKU:
CAB14103
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-599 of human IGF2BP2/IMP2 (NP_006539.3).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
IMP2; IMP-2; VICKZ2; IGF2BP2/IMP2
Positive Sample:
HeLa,Jurkat,Mouse testis,Mouse ovary,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
66kDa
Observed MW:
70kDa
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes.
Purification Method:
Affinity purification
Gene ID:
10644
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGF2BP2/IMP2 Rabbit pAb (CAB14103) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
