The IGF2BP1 Polyclonal Antibody (CAB13581) is a valuable tool for researchers studying IGF2BP1, a protein involved in post-transcriptional regulation of gene expression. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting and immunohistochemistry.IGF2BP1, also known as insulin-like growth factor 2 mRNA-binding protein 1, plays a pivotal role in RNA stabilization and translation, affecting cell growth, differentiation, and tumorigenesis.
Its dysregulation has been implicated in various cancers, making it a promising therapeutic target for cancer treatment.By enabling the detection and analysis of IGF2BP1 in different cell types, this antibody is invaluable for studies in cancer research, developmental biology, and molecular biology. Understanding the function and regulation of IGF2BP1 is essential for uncovering its potential as a biomarker or therapeutic target in cancer and other diseases.
Product Name:
IGF2BP1 Rabbit Polyclonal Antibody
SKU:
CAB13581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 478-577 of human IGF2BP1/IMP1 (NP_006537.3).
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10642
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGF2BP1/IMP1 Rabbit pAb (CAB13581) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
