The IGF1R Polyclonal Antibody (CAB12736) is a valuable tool for researchers studying the insulin-like growth factor 1 receptor (IGF1R), a key player in cell growth and survival pathways. This antibody, produced in rabbits, is highly specific to IGF1R and is suitable for Western blot applications in human samples.IGF1R is a transmembrane receptor that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis. Dysregulation of IGF1R signaling has been implicated in various diseases, including cancer, diabetes, and cardiovascular disorders.
By targeting IGF1R, researchers can gain insight into the underlying mechanisms of these conditions and potentially identify new therapeutic targets.This antibody enables researchers to detect and analyze IGF1R expression levels in different cell types, providing valuable information for studies in molecular biology, oncology, and endocrinology. Understanding the role of IGF1R in disease pathology may lead to the development of targeted therapies that could improve patient outcomes.
Product Name:
IGF1R Rabbit Polyclonal Antibody
SKU:
CAB12736
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 741-910 of human IGF1R (NP_000866.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
155kDa
Observed MW:
100kDa
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3480
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGF1R Rabbit pAb (CAB12736) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
