null

IGF1 Antibody (PACO21295)

SKU:
PACO21295
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€589
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

IGF1 Antibody (PACO21295)

The IGF1 Polyclonal Antibody (PACO21295) is a valuable tool for researchers studying Insulin-like Growth Factor 1 (IGF1), a key player in cell growth and development. This antibody, developed using rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the IGF1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in fields such as oncology and developmental biology.IGF1, a growth factor with a wide range of functions, is involved in processes such as cell proliferation, differentiation, and survival.

Its dysregulation is associated with various diseases, including cancer, diabetes, and neurodegenerative disorders. By investigating the role of IGF1 in these conditions, researchers can gain insights that may lead to the development of novel therapeutic strategies.Overall, the IGF1 Polyclonal Antibody (PACO21295) provides researchers with a reliable tool for exploring the functions and mechanisms of IGF1, making it a valuable asset for advancing research in the fields of biology and medicine.

Antibody Name:IGF1 Antibody (PACO21295)
Antibody SKU:PACO21295
Size:100ul(100ug)
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:A synthetic peptide of human IGF-1
Form:Liquid
Storage Buffer:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:Affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:IGF1, also named as IBP1, MGF, IGF-IA and Somatomedin-C, belongs to the insulin family. IGF1 is structurally and functionally related to insulin but have a much higher growth-promoting activity. Altered expression or mutation of IGF-1 is associated with several human disorders, including type I diabetes and various forms of cancer. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. The antibody is specific to isoform IGF-1A.
UniProt Protein Function:IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptideChromosomal Location of Human Ortholog: 12q23.2Cellular Component: insulin-like growth factor binding protein complex; extracellular space; plasma membrane; extracellular regionMolecular Function: integrin binding; insulin-like growth factor receptor binding; protein binding; growth factor activity; hormone activity; insulin receptor bindingBiological Process: muscle development; positive regulation of transcription, DNA-dependent; chondroitin sulfate proteoglycan biosynthetic process; exocrine pancreas development; glycolate metabolic process; water homeostasis; positive regulation of glucose import; positive regulation of fibroblast proliferation; proteoglycan biosynthetic process; inner ear development; positive regulation of DNA binding; muscle hypertrophy; platelet activation; positive regulation of protein import into nucleus, translocation; positive regulation of mitosis; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; branching morphogenesis of a tube; regulation of gene expression; response to heat; positive regulation of transcription from RNA polymerase II promoter; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of insulin-like growth factor receptor signaling pathway; myoblast proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of glycogen biosynthetic process; positive regulation of activated T cell proliferation; positive regulation of smooth muscle cell migration; signal transduction; negative regulation of cell proliferation; glial cell differentiation; platelet degranulation; mammary gland development; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; DNA replication; skeletal development; positive regulation of granule cell precursor proliferation; phosphoinositide-mediated signaling; multicellular organism growth; myotube cell development; regulation of multicellular organism growth; satellite cell compartment self-renewal involved in skeletal muscle regeneration; myoblast differentiation; positive regulation of protein kinase B signaling cascade; positive regulation of osteoblast differentiation; cell proliferation; cellular protein metabolic process; positive regulation of tyrosine phosphorylation of Stat5 protein; Ras protein signal transduction; positive regulation of glycolysis; blood vessel remodeling; positive regulation of Ras protein signal transduction; cell motility; blood coagulation; positive regulation of DNA replicationDisease: Insulin-like Growth Factor I Deficiency
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
UniProt Code:P01343
NCBI GenInfo Identifier:11024682
NCBI Gene ID:3479
NCBI Accession:NP_000609.1
UniProt Secondary Accession:P01343
UniProt Related Accession:P01343,P05019
Molecular Weight:
NCBI Full Name:insulin-like growth factor I isoform 4 preproprotein
NCBI Synonym Full Names:insulin like growth factor 1
NCBI Official Symbol:IGF1  
NCBI Official Synonym Symbols:IGF; MGF; IGFI; IGF-I  
NCBI Protein Information:insulin-like growth factor I
UniProt Protein Name:Insulin-like growth factor I
UniProt Synonym Protein Names:Mechano growth factor; MGF; Somatomedin-C
Protein Family:Adropin
UniProt Gene Name:IGF1  
UniProt Entry Name:IGF1_HUMAN

Related Products