The IFT88 Polyclonal Antibody (CAB13054) is a valuable tool for researchers studying the intraflagellar transport (IFT) protein 88, which is essential for the assembly of cilia - microtubule-based structures found on the surface of many cell types. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.IFT88 is a key player in ciliogenesis and ciliary function, playing a crucial role in various cellular processes such as cell signaling, sensory perception, and motility. Dysregulation of IFT88 has been linked to ciliopathies, a group of genetic disorders characterized by abnormal cilia structure and function.
Research on IFT88 is essential for understanding the molecular mechanisms underlying these diseases and exploring potential therapeutic interventions.By targeting the IFT88 protein, the polyclonal antibody enables the detection and analysis of IFT88 in different cell types, making it an invaluable tool for studies in cell biology, developmental biology, and genetics. Its versatility and specificity make it a valuable asset for researchers looking to unravel the complex roles of IFT88 in health and disease.
Product Name:
IFT88 Rabbit Polyclonal Antibody
SKU:
CAB13054
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 534-833 of human IFT88 (NP_783195.2).
This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
8100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat testis, using IFT88 Rabbit pAb (CAB13054) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
