The IFT88 Monoclonal Antibody is a specialized tool for research involving IFT88, a critical component of the primary cilium and intracellular transport system. This antibody, generated from hybridoma cells, is highly specific for IFT88 and is validated for use in various applications, including immunofluorescence and immunoprecipitation.IFT88, known as intraflagellar transport protein 88, plays a crucial role in ciliary assembly and maintenance, mediating the transport of proteins within the cilium. Dysregulation of IFT88 has been linked to ciliopathies, genetic disorders affecting cilia function, as well as various developmental abnormalities and diseases.
By targeting IFT88, researchers can investigate the function and regulation of ciliary transport processes, providing insights into the molecular mechanisms underlying ciliopathies and related conditions. The IFT88 Monoclonal Antibody offers a reliable tool for studying cilia biology and uncovering potential therapeutic targets for ciliopathies and other disorders.
This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
8100
Clone Number:
ARC57206
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IFT88 antibody (CAB22622) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
