The IFT52 Antibody (PAC061265) is a high-quality research tool designed for studying the protein IFT52, a vital component of the intraflagellar transport (IFT) complex essential for ciliary assembly and maintenance. This polyclonal antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.By targeting the IFT52 protein, this antibody enables researchers to easily detect and analyze its expression in various cell types. The IFT complex, of which IFT52 is a part, plays a crucial role in ciliary function and signaling pathways, making it a valuable target for studies in cell biology and developmental biology.
Understanding the function and regulation of IFT52 can provide insights into ciliary-related diseases, such as ciliopathies and certain genetic disorders. By studying the role of IFT52 in ciliary transport and signaling, researchers can uncover potential therapeutic targets for these conditions. The IFT52 Antibody is an essential tool for unraveling the complexities of ciliary biology and its implications in human health and disease.
Antibody Name:
IFT52 Antibody (PACO61265)
Antibody SKU:
PACO61265
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Intraflagellar transport protein 52 homolog protein (325-434AA)
Western Blot. Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate. All lanes: IFT52 antibody at 5.1µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.
Background:
Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Required for the anterograde transport of IFT88.
Synonyms:
Intraflagellar transport protein 52 homolog (Protein NGD5 homolog), IFT52, C20orf9 NGD5
UniProt Protein Function:
Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:27466190). Required for the anterograde transport of IFT88 (PubMed:27466190).
UniProt Protein Details:
NCBI Summary:
This gene encodes a conserved proline-rich protein that is a component of the intraflagellar transport-B (IFT-B) core complex. The encoded protein is essential for the integrity of the IFT-B core complex, and for biosynthesis and maintenance of cilia. Mutations in this gene are associated with ciliopathy that affects the skeleton. [provided by RefSeq, Oct 2016]
