The IFT27 Polyclonal Antibody (PAC041262) is a valuable tool for researchers studying IFT27, a key protein involved in the process of intraflagellar transport (IFT) within cilia. This antibody, produced in rabbits, has high specificity for detecting IFT27 in human samples and has been validated for use in Western blot applications. By binding to the IFT27 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for research in the fields of cell biology and ciliary function.IFT27 plays a crucial role in regulating the transport of protein complexes within cilia, which is essential for maintaining the structure and function of these hair-like structures present on many cell types.
Dysregulation of IFT27 function has been implicated in a variety of ciliopathies and genetic disorders, making it a promising target for further research in these areas. By understanding the function of IFT27, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies to treat them.
Antibody Name:
IFT27 Antibody (PACO41262)
Antibody SKU:
PACO41262
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Intraflagellar transport protein 27 homolog protein (1-186AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO41262 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO41262 at dilution of 1:100.
Background:
Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity).
Synonyms:
Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4), IFT27, RABL4 RAYL
UniProt Protein Function:
RABL4: Possesses GTPase activity. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein; G protein, monomeric; G protein, monomeric, RasChromosomal Location of Human Ortholog: 22q13.1Cellular Component: ciliumMolecular Function: protein bindingBiological Process: intracellular protein transport; intraflagellar transport; smoothened signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
