The IFNLR1 Polyclonal Antibody (CAB10082) is a valuable tool for researchers studying the IFNLR1 protein, a key component of the Type III interferon receptor complex. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically recognizing the IFNLR1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in immunology and viral infection research.IFNLR1, also known as IFN-λ receptor 1, is essential for the signaling cascade triggered by Type III interferons, which play a crucial role in antiviral defense and immune response modulation.
The involvement of IFNLR1 in these processes positions it as a promising target for research into infectious diseases, autoimmune disorders, and viral pathogenesis. Understanding the function and regulation of IFNLR1 could provide valuable insights for the development of novel therapeutics that modulate immune responses in these pathological conditions.
Product Name:
IFNLR1 Rabbit Polyclonal Antibody
SKU:
CAB10082
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-228 of human IFNLR1 (NP_734464.1).
HT-29,Jurkat,MCF7,Mouse lung,Mouse heart,Mouse small intestine,Rat lung,Rat heart
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Single-pass type I membrane protein.
Calculated MW:
58kDa
Observed MW:
53kDa
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
163702
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IFNLR1 antibody (CAB10082) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
