The IFNGR2 Polyclonal Antibody (CAB7558) is specifically designed for research involving IFNGR2, a key component of the interferon-gamma signaling pathway. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By targeting the IFNGR2 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in immunology, infectious diseases, and cancer research.IFNGR2, also known as interferon gamma receptor 2, plays a crucial role in mediating the effects of interferon-gamma, a key cytokine involved in immune responses.
Understanding the function and regulation of IFNGR2 is essential for studying immune signaling pathways and developing targeted therapies for diseases such as cancer, autoimmune disorders, and infectious diseases. The IFNGR2 Polyclonal Antibody is a valuable tool for researchers investigating the role of IFNGR2 in health and disease.
Product Name:
IFNGR2 Rabbit Polyclonal Antibody
SKU:
CAB7558
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 238-337 of human IFNGR2 (NP_005525.2).
Sequence:
KDSS PKDD VWDS VSI
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
AF-1; IFGR2; IMD28; IFNGT1; IFNGR2
Positive Sample:
HeLa,F9
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Single-pass type I membrane protein.
Calculated MW:
38kDa
Observed MW:
38kDa
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
Purification Method:
Affinity purification
Gene ID:
3460
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IFNGR2 antibody (CAB7558) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
