The IFNAR2 Polyclonal Antibody (CAB21462) is a valuable tool for researchers studying the interferon alpha and beta receptor subunit 2 (IFNAR2) protein. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to IFNAR2, researchers can detect and analyze this critical protein involved in the cellular response to interferons.IFNAR2 is essential for the signaling pathways activated by interferon alpha and beta, which play a crucial role in the immune response to viral infections and other pathogens. Dysregulation of the interferon signaling pathway has been implicated in various diseases, including autoimmune disorders, viral infections, and cancer.
Thus, understanding the function of IFNAR2 is vital for developing targeted therapies that modulate the immune response in these pathological conditions.Overall, the IFNAR2 Polyclonal Antibody is a valuable tool for researchers investigating the role of IFNAR2 in immune response modulation and disease pathogenesis. Its high specificity and reactivity with human samples make it an essential asset for studies in immunology, virology, and cancer research.
Product Name:
IFNAR2 Polyclonal Antibody
SKU:
CAB21462
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-243 of human IFNAR2 (NP_997468.1).
Membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
27kDa/37kDa/57kDa
Observed MW:
95kDa
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45.
Purification Method:
Affinity purification
Gene ID:
3455
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using [KO Validated] IFNAR2 Rabbit pAb (CAB21462) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
