IFNA2 Rabbit Polyclonal Antibody (CAB17316)
- SKU:
- CAB17316
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | IFNA2 Rabbit Polyclonal Antibody |
SKU: | CAB17316 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human Interferon alpha 2 (IFN-α2) (NP_000596.2). |
Sequence: | DETL LDKF YTEL YQQL NDLE ACVI QGVG VTET PLMK EDSI LAVR KYFQ RITL YLKE KKYS PCAW EVVR AEIM RSFS LSTN LQES LRSK E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | IFNA; IFNA2B; leIF A; IFN-alphaA; IFN-alpha-2; Interferon alpha 2 (IFN-α2) |
Positive Sample: | U-937,SP2/0 |
Cellular Localization: | extracellular region, extracellular space |
Calculated MW: | 22kDa |
Observed MW: | 15kDa |
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach.
Purification Method: | Affinity purification |
Gene ID: | 3440 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |