The IFITM5 Polyclonal Antibody (PAC045926) is a research tool designed for the study of IFITM5, a cell surface protein involved in bone mineralization and calcium phosphate crystal formation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding to the IFITM5 protein, researchers can investigate its role in osteoblast differentiation and mineralization processes in various cell types, making it a valuable tool for bone biology and skeletal development studies.
IFITM5, also known as Bone Restricted IFITM-like protein (BRIL), is essential for proper bone formation and mineralization, playing a crucial role in skeletal development and maintenance. Mutations in the IFITM5 gene have been associated with osteogenesis imperfecta, a genetic disorder characterized by brittle bones and susceptibility to fractures. Research on IFITM5 is essential for understanding the molecular mechanisms underlying bone formation and mineralization, as well as for developing potential therapeutic strategies for bone-related disorders.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO45926 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO45926 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Required for normal bone mineralization.
Synonyms:
Interferon-induced transmembrane protein 5 (Bone-restricted interferon-induced transmembrane protein-like protein) (BRIL) (Dispanin subfamily A member 1) (DSPA1), IFITM5
UniProt Protein Function:
IFITM5: Plays a role in bone mineralization. Belongs to the CD225/Dispanin family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11p15.5Cellular Component: integral to plasma membraneBiological Process: bone mineralizationDisease: Osteogenesis Imperfecta, Type V
UniProt Protein Details:
NCBI Summary:
This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]
