The IFI16 Polyclonal Antibody (CAB14002) is a vital tool for researchers investigating IFI16, a protein involved in immune responses and inflammation. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the IFI16 protein, this antibody facilitates the detection and analysis of IFI16 in various cell types.IFI16, a member of the interferon-inducible HIN-200 family of proteins, plays a key role in the detection of viral and bacterial DNA in the cytoplasm, triggering immune responses to combat infections.
Its involvement in innate immune signaling pathways makes it a promising target for studies in immunology, virology, and inflammatory diseases. Understanding the function of IFI16 is crucial for advancing knowledge on host defense mechanisms and developing therapeutics for infectious and inflammatory conditions.
Product Name:
IFI16 Rabbit Polyclonal Antibody
SKU:
CAB14002
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human IFI16 (NP_001351796.1).
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3428
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IFI16 Rabbit pAb (CAB14002) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.5s.
