The IDS Polyclonal Antibody (CAB1857) is a valuable tool for researchers studying the IDS gene, which encodes for the iduronate-2-sulfatase enzyme. This enzyme is essential for the breakdown of glycosaminoglycans (GAGs) in the body, making it crucial for proper cellular function and development. The IDS antibody, produced in rabbits, is highly specific to human samples and has been validated for use in applications such as Western blotting.By targeting the IDS protein, this antibody enables researchers to detect and analyze IDS expression in various cell types, providing insight into its role in lysosomal storage disorders such as Hunter syndrome.
Understanding the function of IDS is critical for developing treatments and therapies for individuals affected by these rare genetic conditions.Overall, the IDS Polyclonal Antibody (CAB1857) is a valuable tool for researchers investigating lysosomal storage disorders and the role of IDS in cellular metabolism and health. Its high specificity and reactivity make it an ideal choice for studies in molecular biology, biochemistry, and genetic medicine.
Product Name:
IDS Rabbit Polyclonal Antibody
SKU:
CAB1857
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 34-290 of human IDS (NP_000193.1).
This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
3423
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using IDS Rabbit pAb (CAB1857) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
