The IDO2 Polyclonal Antibody (PAC027S) is a valuable tool for researchers investigating the role of IDO2 in immune regulation and cancer development. This highly reactive antibody, produced in rabbits, is specifically designed for use in Western blot applications and is validated for its ability to bind to the IDO2 protein in human samples.IDO2, a key enzyme in the tryptophan catabolism pathway, has been implicated in immune tolerance and the regulation of T cell function. Its overexpression has been linked to cancer progression and immune evasion, making it a promising target for therapeutic interventions.
By using the IDO2 Polyclonal Antibody, researchers can accurately detect and analyze IDO2 expression in various cell types, providing valuable insights into its role in immunology and cancer research.With its ability to target IDO2, this antibody offers researchers a powerful tool for studying the molecular mechanisms underlying immune dysfunction and cancer immune escape. By further understanding the functions of IDO2, researchers can potentially develop novel therapies to target this enzyme and improve treatment outcomes for patients with cancer and other immune-related disorders.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO27497 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO27497 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO27497 at dilution of 1:100.
Background:
Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.
Synonyms:
Indoleamine 2,3-dioxygenase 2 (IDO-2) (EC 1.13.11.-) (Indoleamine 2,3-dioxygenase-like protein 1) (Indoleamine-pyrrole 2,3-dioxygenase-like protein 1), IDO2, INDOL1
UniProt Protein Function:
INDOL1: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Belongs to the indoleamine 2,3-dioxygenase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.-Chromosomal Location of Human Ortholog: 8p11.21Cellular Component: cytoplasm; cytosolMolecular Function: metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activityBiological Process: tryptophan catabolic process to kynurenine; tryptophan catabolic process
UniProt Protein Details:
NCBI Summary:
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
