The IDO2 Polyclonal Antibody (PAC002183) is a valuable tool for research involving the IDO2 protein, an enzyme involved in immune regulation and tolerance. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the IDO2 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an ideal choice for studies in immunology, cancer, and other related fields.IDO2, a member of the indoleamine 2,3-dioxygenase (IDO) family, plays a crucial role in regulating immune responses through the metabolism of tryptophan.
Its involvement in immune tolerance and inflammation makes it a promising target for research into diseases like cancer, autoimmune disorders, and infectious diseases. Understanding the function of IDO2 could lead to the development of novel therapies aimed at modulating immune responses in these conditions.Overall, the IDO2 Polyclonal Antibody is a valuable tool for scientists seeking to explore the role of IDO2 in immune regulation and related diseases. Its high reactivity and specificity make it a reliable choice for a variety of research applications in the field of immunology and beyond.
Antibody Name:
IDO2 Antibody
Antibody SKU:
PACO02183
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human INDOL1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
IDO2; INDOL1; Indoleamine 2,3-dioxygenase 2; IDO-2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
UniProt Protein Function:
INDOL1: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Belongs to the indoleamine 2,3-dioxygenase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.-Chromosomal Location of Human Ortholog: 8p11.21Cellular Component: cytoplasm; cytosolMolecular Function: metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activityBiological Process: tryptophan catabolic process to kynurenine; tryptophan catabolic process
UniProt Protein Details:
NCBI Summary:
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
