IDO1 Rabbit Polyclonal Antibody (CAB1614)
- SKU:
- CAB1614
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | IDO1 Rabbit Polyclonal Antibody |
SKU: | CAB1614 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-403 of human IDO1 (NP_002155.1). |
Sequence: | MAHA MENS WTIS KEYH IDEE VGFA LPNP QENL PDFY NDWM FIAK HLPD LIES GQLR ERVE KLNM LSID HLTD HKSQ RLAR LVLG CITM AYVW GKGH GDVR KVLP RNIA VPYC QLSK KLEL PPIL VYAD CVLA NWKK KDPN KPLT YENM DVLF SFRD GDCS KGFF LVSL LVEI AAAS AIKV IPTV FKAM QMQE RDTL LKAL LEIA SCLE KALQ VFHQ IHDH VNPK AFFS VLRI YLSG WKGN PQLS DGLV YEGF WEDP KEFA GGSA GQSS VFQC FDVL LGIQ QTAG GGHA AQFL QDMR RYMP PAHR NFLC SLES NPSV REFV LSKG DAGL REAY DACV KALV SLRS YHLQ IVTK YILI PASQ QPKE NKTS EDPS KLEA KGTG GTDL MNFL KTVR STTE KSLL KEG |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | IDO; INDO; IDO-1; IDO1 |
Positive Sample: | SKOV3,A-549 cells treated by hIFN-γ |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytosol. |
Calculated MW: | 45kDa |
Observed MW: | 43kDa |
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Purification Method: | Affinity purification |
Gene ID: | 3620 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |