IDH2 Rabbit Polyclonal Antibody (CAB7190)
- SKU:
- CAB7190
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- IP
- ChIP
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | IDH2 Rabbit Polyclonal Antibody |
SKU: | CAB7190 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 193-452 of human IDH2 (NP_002159.2). |
Sequence: | KMVF TPKD GSGV KEWE VYNF PAGG VGMG MYNT DESI SGFA HSCF QYAI QKKW PLYM STKN TILK AYDG RFKD IFQE IFDK HYKT DFDK NKIW YEHR LIDD MVAQ VLKS SGGF VWAC KNYD GDVQ SDIL AQGF GSLG LMTS VLVC PDGK TIEA EAAH GTVT RHYR EHQK GRPT STNP IASI FAWT RGLE HRGK LDGN QDLI RFAQ MLEK VCVE TVES GAMT KDLA GCIH GLSN VKLN EHFL NTTD FLDT IKSN LDRA LGRQ |
Tested Applications: | WB IHC-P IF/ICC IP ChIP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:20 - 1:50 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cellsChIP,5μg antibody for 10μg-15μg of Chromatin |
Synonyms: | IDH; IDP; IDHM; IDPM; ICD-M; IDH-2; D2HGA2; mNADP-IDH; IDH2 |
Positive Sample: | Jurkat,Mouse heart,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion. |
Calculated MW: | 51kDa |
Observed MW: | 43kDa |
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3418 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |