IDH1 Monoclonal Antibody [PAT25H10AT] (CPAB0231)
- SKU:
- CPAB0231
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- PAT25H10AT
- Applications:
- ELISA
- FC
Description
IDH1 Monoclonal Antibody [PAT25H10AT] (CPAB0231)
The IDH1 Polyclonal Antibody (CPAB0231) is a valuable tool for researchers studying IDH1, a key enzyme involved in cellular metabolism and implicated in a variety of diseases, including gliomas and other cancers. This antibody, raised in rabbits, is highly specific for human IDH1 and has been validated for use in Western blot applications.IDH1 is a critical enzyme in the citric acid cycle, playing a key role in the production of energy within cells. Mutations in IDH1 have been linked to various cancers, making it an important target for cancer research. This antibody binds specifically to IDH1, allowing for the detection and analysis of this enzyme in various cell types.
Research into IDH1 is crucial for understanding the biochemical pathways involved in cancer development and progression. By studying the activity of IDH1, researchers can gain valuable insights into the mechanisms underlying cancer growth and potentially identify new therapeutic targets. The IDH1 Polyclonal Antibody is a valuable tool for researchers investigating the role of IDH1 in cancer and other diseases, aiding in the advancement of scientific knowledge and the development of potential treatments.
| Product Name: | IDH1 Antibody |
| Product Sku: | CPAB0231 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human IDH1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human IDH1 protein 1-414 amino acids purified from Ecoli. |
| Clone: | PAT25H10AT. |
| Reactivity: | Human |
| Applications: | ELISA, Flow Cytometry |
| Purification Method: | IDH1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
| Isotype: | IgG2a |
| Background: | Isocitrate Dehydrogenase is an enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. |
| Synonyms: | Isocitrate dehydrogenase [NADP] cytoplasmic, EC 1.1.1.42, Cytosolic NADP-isocitrate dehydrogenase, Oxalosuccinate decarboxylase, IDH, NADP(+)-specific ICDH, IDP, PICD. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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