Insulin-degrading enzyme (IDE) Rabbit Monoclonal Antibody (CAB11190)
- SKU:
- CAB11190
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | Insulin-degrading enzyme (IDE) Rabbit Monoclonal Antibody |
SKU: | CAB11190 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Insulin-degrading enzyme (IDE) (P14735). |
Sequence: | MRYR LAWL LHPA LPST FRSV LGAR LPPP ERLC GFQK KTYS KMNN PAIK RIGN HITK SPED KREY RGLE LANG IKVL LISD PTTD KSSA ALDV HIGS LSDP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | INSULYSIN; Insulin-degrading enzyme (IDE) |
Positive Sample: | HepG2,K-562,U-87MG,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Secreted. |
Calculated MW: | 118kDa |
Observed MW: | 118kDa |
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
Purification Method: | Affinity purification |
Gene ID: | 3416 |
Clone Number: | ARC0537 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |