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ICT1 Monoclonal Antibody [PAT1E9A] (CPAB0587)

SKU:
CPAB0587
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT1E9A
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

ICT1 Monoclonal Antibody [PAT1E9A] (CPAB0587)

The ICT1 Polyclonal Antibody (CPAB0587) is a valuable tool for researchers studying ICT1, a protein involved in mitochondrial translation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the ICT1 protein, this antibody allows for the detection and analysis of ICT1 in various cell types, making it ideal for research in mitochondrial biology and disease.ICT1 plays a crucial role in the translation of mitochondrial genes, making it essential for proper mitochondrial function and energy production.

Dysregulation of ICT1 has been implicated in diseases such as mitochondrial disorders and certain types of cancer. Studying the function and regulation of ICT1 is key to understanding these disease processes and developing potential therapeutic interventions.Overall, the ICT1 Polyclonal Antibody is a reliable tool for researchers interested in exploring the role of ICT1 in mitochondrial translation and its implications for human health. Its high specificity and sensitivity make it a valuable asset for studies in cell biology, biochemistry, and molecular biology.

Product Name:ICT1 Antibody
Product Sku:CPAB0587
Size:5μg
Host Species:Mouse
Immunogen:Anti-human ICT1 mAb, clone PAT1E9A, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ICT1 protein 3-26 amino acids  purified from Ecoli.
Clone:PAT1E9A.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:ICT1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Immature Colon Carcinoma Transcript 1 (ICT1) functions as a codon-independent translation release factor that has lost all stop codon specificity and leads the termination of translation in mitochondrion in case of abortive elongation. The mature colon epithelium has 3 differentiated cell types which arise from a multipotent stem cell. ICT1 is involved in the hydrolysis of peptidyl-tRNAs which have been prematurely terminated and consequently in the recycling of stalled mitochondrial ribosomes. Digression from the normal maturation pathway by neoplastic transformation is assumed to originate in stem cells or their early descendants.
Synonyms:DS-1, DS1, Peptidyl-tRNA hydrolase ICT1 mitochondrial, Digestion substraction 1, Immature colon carcinoma transcript 1 protein, ICT1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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