The ICOS Rabbit Monoclonal Antibody (CAB5130) is a highly specific and reliable tool for studying the immune checkpoint molecule Inducible T-cell Costimulator (ICOS). This antibody, produced using rabbit monoclonal technology, is optimized for detection of ICOS protein in human samples and is validated for use in various applications such as Western blot, immunohistochemistry, and flow cytometry.ICOS is a crucial co-stimulatory molecule expressed on activated T cells and plays a key role in regulating T cell function and immune responses. Dysregulation of ICOS signaling has been implicated in various autoimmune disorders, allergies, and cancer, making it a promising target for therapeutic interventions.
The ICOS Rabbit Monoclonal Antibody allows for precise detection and analysis of ICOS expression in different cell types, providing valuable insights for research in immunology, oncology, and autoimmune diseases.By utilizing the ICOS Rabbit Monoclonal Antibody, researchers can further explore the mechanisms underlying immune regulation and develop novel strategies for immunotherapy and precision medicine. Its high specificity and sensitivity make it an essential tool for advancing our understanding of ICOS biology and its potential therapeutic applications.
Product Name:
ICOS/CD278 Rabbit Monoclonal Antibody
SKU:
CAB5130
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ICOS/CD278 (Q9Y6W8).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
23kDa
Observed MW:
22kDa
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Purification Method:
Affinity purification
Gene ID:
29851
Clone Number:
ARC1148
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ICOS/CD278 Rabbit mAb (CAB5130) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
