The ICMT Polyclonal Antibody (CAB10293) is a valuable tool for researchers studying protein prenylation processes and their impact on cell signaling and function. This antibody, generated in rabbits, specifically binds to the ICMT protein, allowing for accurate detection and analysis in a variety of cell types.ICMT, or isoprenylcysteine carboxyl methyltransferase, is an essential enzyme involved in the post-translational modification of certain proteins, particularly those involved in signal transduction pathways. By targeting ICMT with this antibody, researchers can gain insights into its role in cellular processes and its potential as a therapeutic target for diseases such as cancer and cardiovascular disorders.
With its high reactivity towards human samples and validation for use in Western blot applications, the ICMT Polyclonal Antibody is a reliable tool for scientists conducting studies in biochemistry, cell biology, and drug discovery. By elucidating the functions of ICMT, researchers can contribute to the development of novel treatments and interventions for various diseases and conditions.
Product Name:
ICMT Rabbit Polyclonal Antibody
SKU:
CAB10293
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 175-284 of human ICMT (NP_036537.1).
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.
Purification Method:
Affinity purification
Gene ID:
23463
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ICMT Rabbit pAb (CAB10293) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
