The ICAM4 Polyclonal Antibody (CAB7438) is a valuable tool for researchers studying ICAM4, a cell surface glycoprotein involved in immune responses and inflammation. This antibody is produced in rabbits and shows high reactivity with human samples, making it an essential component for experiments involving ICAM4 detection.Validated for use in Western blot applications, the ICAM4 Polyclonal Antibody binds specifically to the ICAM4 protein, allowing for precise and accurate analysis in a variety of cell types. Its versatility and reliability make it an ideal choice for studies focusing on immunology, inflammation, and related fields.ICAM4, also known as intercellular adhesion molecule-4, plays a crucial role in leukocyte adhesion and migration, making it a key player in the immune response and inflammatory processes.
Research on ICAM4 is essential for understanding its functions in diseases such as autoimmune disorders, inflammatory conditions, and cancer, where abnormal expression or activity of ICAM4 may contribute to pathology.By using the ICAM4 Polyclonal Antibody, researchers can gain valuable insights into the role of ICAM4 in various physiological and pathological processes, paving the way for new therapeutic strategies and interventions targeting ICAM4 in disease treatment and management.
Product Name:
ICAM4 Rabbit Polyclonal Antibody
SKU:
CAB7438
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ICAM4 (NP_001034221.1).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
29kDa
Observed MW:
29kDa
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
3386
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ICAM4 antibody (CAB7438) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
