The ICAM3 Polyclonal Antibody (CAB3923) is a valuable tool for researchers studying ICAM3, a cell surface glycoprotein involved in immune cell adhesion and signaling. This antibody, produced in rabbits, displays high specificity for human samples and has been validated for use in Western blot applications. By binding to the ICAM3 protein, it enables precise detection and analysis in various cell types, making it ideal for investigations in immunology and inflammatory diseases.ICAM3, also known as intercellular adhesion molecule 3, plays a crucial role in immune response regulation by facilitating interactions between immune cells and promoting immune cell activation.
Its function in mediating cell adhesion and immune cell communication make it a key target for research on autoimmune disorders, infectious diseases, and inflammatory conditions. Studying the role of ICAM3 can provide valuable insights into immune cell behavior and aid in the development of targeted therapies for immune-related disorders.
Product Name:
ICAM3 Rabbit Polyclonal Antibody
SKU:
CAB3923
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 270-490 of human ICAM3 (NP_002153.2).
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
3385
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of U-937, using ICAM3 antibody (CAB3923) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
