The ICAM1 Polyclonal Antibody is a vital tool for research involving intercellular adhesion molecule 1 (ICAM1), a cell surface glycoprotein involved in various biological processes, including immune responses and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ICAM1 protein, this antibody enables the detection and analysis of ICAM1 expression in a wide range of cell types, making it an essential tool for studies in immunology, inflammatory diseases, and cancer research.ICAM1 plays a crucial role in mediating the adhesion between immune cells and endothelial cells, facilitating immune cell trafficking and inflammation.
Its dysregulation has been implicated in various diseases, including inflammatory disorders, autoimmune diseases, and cancer. By understanding the functions and regulation of ICAM1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.In summary, the ICAM1 Polyclonal Antibody is a highly specific and sensitive tool for investigating ICAM1 expression and function in various research contexts. Its utility in studying immune cell adhesion and inflammation makes it a valuable asset for researchers seeking to deepen their understanding of immune-related diseases and develop new treatment strategies.
Product Name:
Icam1 Polyclonal Antibody
SKU:
CAB23661
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant protein of rat Icam1.
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:
CD54; ICAM; Icam1
Positive Sample:
Mouse spleen,Mouse lung,Rat spleen,Rat lung
Conjugate:
Unconjugated
Calculated MW:
60kDa
Observed MW:
102kDa
Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1).
Purification Method:
Affinity purification
Gene ID:
25464
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Icam1 Rabbit pAb (CAB23661) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
