The ICA1 Polyclonal Antibody (CAB17500) is a rabbit polyclonal antibody designed for research involving ICA1, a protein known for its involvement in diabetes and pancreatic beta cell function. This highly reactive antibody is validated for use in various applications, including Western blotting and immunohistochemistry. By binding to the ICA1 protein, this antibody enables precise detection and analysis in a wide range of samples, making it an invaluable tool for studies in diabetes research and endocrinology.ICA1, also known as islet cell autoantigen 1, is a key player in the regulation of insulin secretion and glucose homeostasis.
Its role in pancreatic beta cell function and the pathogenesis of diabetes makes it a crucial target for understanding the mechanisms underlying this disease. Research into ICA1 can provide insights into potential therapeutic strategies for managing diabetes and addressing related complications, ultimately contributing to the development of innovative treatments in the field of endocrinology.
Product Name:
ICA1 Rabbit Polyclonal Antibody
SKU:
CAB17500
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human ICA1 (NP_001263407).
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3382
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ICA1 Rabbit pAb (CAB17500) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
