The IBTK Polyclonal Antibody (CAB14866) is a valuable tool for researchers studying IBTK, a protein involved in various cellular processes including cell cycle regulation and DNA damage response. This antibody, raised in rabbits, is highly specific to IBTK and is suitable for use in Western blot applications with human samples. By binding to the IBTK protein, this antibody enables accurate detection and analysis of IBTK levels in a variety of cell types, making it an essential component of studies focusing on cell biology and cancer research.
IBTK, also known as inhibitor of Bruton's tyrosine kinase, plays a crucial role in regulating cell growth and survival pathways, making it an attractive target for exploring potential therapeutic interventions in diseases like cancer and neurological disorders. The IBTK Polyclonal Antibody facilitates the investigation of IBTK function, offering insights into its role in disease progression and highlighting its potential as a therapeutic target for future drug development efforts.
Product Name:
IBTK Rabbit Polyclonal Antibody
SKU:
CAB14866
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 900-1200 of human IBTK (NP_056340.2).
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
25998
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IBTK Rabbit pAb (CAB14866) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
