The IBA1 Polyclonal Antibody (CAB3160) is a key tool for researchers studying IBA1, a protein marker for microglia, a type of immune cell in the brain. This antibody, produced in rabbits, is highly specific to human IBA1 and has been validated for use in Western blot and immunohistochemistry applications. By binding to IBA1 protein, this antibody allows for accurate detection and analysis of microglia in various experimental settings, making it essential for neuroscience and neuroinflammation research.IBA1, also known as ionized calcium-binding adapter molecule 1, is a marker for activated microglia, which play a crucial role in regulating the brain's immune response.
Studies have shown that IBA1 expression is increased in neuroinflammatory conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By understanding the role of IBA1 in these diseases, researchers can develop targeted therapies to modulate microglia activity and potentially treat neuroinflammatory disorders effectively.
Product Name:
Iba1 Rabbit Polyclonal Antibody
SKU:
CAB3160
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human AIF1/IBA1 (P55008).
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Purification Method:
Affinity purification
Gene ID:
199
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Rat brain using AIF1/IBA1 Rabbit pAb (CAB3160) at dilution of 1:50 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
