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IκBα Polyclonal Antibody (CAB21510)

SKU:
CAB21510
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$155 - $431
Frequently bought together:

Description

IκBα Polyclonal Antibody (CAB21510)

The I-B Polyclonal Antibody (CAB21510) is a vital tool for researchers studying the CD300A protein, an immune regulatory molecule involved in immune response inhibition. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is suitable for Western blot applications. By specifically binding to the CD300A protein, researchers can easily detect and analyze its presence in a variety of cell types, making it an excellent choice for studies in immunology and cancer research.

CD300A, also known as an immune inhibitory receptor, plays a crucial role in maintaining immune balance by regulating inflammation and suppressing allergic reactions. Its role in immune response regulation makes it a promising target for research on diseases like cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CD300A is essential for developing treatments that either enhance or suppress immune activity in these disease settings.

Product Name:IκBα Polyclonal Antibody
Product Code:CAB21510
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, Nucleus

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human IκBα (NP_065390.1).
Sequence:MFQAA ERPQE WAMEG PRDGL KKERL LDDRH DSGLD SMKDE EYEQM VKELQ EIRLE PQEVP RGSEP WKQQL TEDGD SFLHL AIIHE EKALT MEVIR QVKGD LAFLN FQNNL QQTPL HLAVI TNQPE IAEAL LGAGC DPELR DFRGN TPLHL ACEQG CLASV GVLTQ SCTTP HLHSI LKATN YNGHT CLHLA SIHGY LGIVE LLVSL GADVN AQEPC NGRTA LHLAV DLQNP DLVSL LLKCG ADVNR VTYQG YSPYQ LTWGR PSTRI QQQLG QLTLE NLQML PESED EESYD TESEF TEFTE DELPY DDCVF GGQRL TL
Synonyms:IKBA, MAD-3, NFKBI, EDAID2
Calculated MW:36kDa
Observed MW:Refer to figures

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