The Hyal1 Monoclonal Antibody is an essential tool for research involving the Hyal1 enzyme, which plays a crucial role in the degradation of hyaluronic acid in the body. This antibody, produced through monoclonal technology, offers high specificity and sensitivity in detecting Hyal1 in various biological samples.Hyal1 is known for its involvement in processes related to tissue remodeling, inflammation, and cell migration, making it a key player in various physiological and pathological conditions. By targeting this enzyme with the Hyal1 Monoclonal Antibody, researchers can gain insights into its functions and mechanisms of action, paving the way for potential therapeutic strategies in diseases such as cancer, arthritis, and cardiovascular disorders.
This antibody is rigorously validated for use in techniques such as immunohistochemistry, immunofluorescence, and flow cytometry, providing researchers with versatile options for studying Hyal1 expression and localization in different cell types and tissues. With its reliable performance and broad applicability, the Hyal1 Monoclonal Antibody is a valuable asset for advancing research in cell biology, biochemistry, and disease mechanisms.
Product Name:
HYAL1 Monoclonal Antibody
SKU:
CAB23834
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-435 of human HYAL1(NP_149349.2).
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3373
Clone Number:
ARC62100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using HYAL1 Rabbit mAb (CAB23834) at 1:1500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): MOLT-4Exposure time: 60s.
