The HUS1B Polyclonal Antibody (CAB14655) is a valuable tool for researchers studying HUS1B, a crucial component of the DNA damage response pathway. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the HUS1B protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in molecular biology and cancer research.
HUS1B is known for its role in sensing DNA damage and initiating repair mechanisms to maintain genetic integrity. Dysfunction in this pathway has been linked to cancer development and progression, highlighting the importance of studying HUS1B in the context of oncology research. By understanding the functions of HUS1B, researchers can gain valuable insights into the mechanisms of DNA repair and potential therapeutic targets for cancer treatment.
Product Name:
HUS1B Rabbit Polyclonal Antibody
SKU:
CAB14655
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human HUS1B (NP_683762.2).
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1.
Purification Method:
Affinity purification
Gene ID:
135458
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HUS1B antibody (CAB14655) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
